Kevin Davis-Walton, a 54-year-old chef at Connaught Halls of Residence, has been missing now for 15 days.
He has not been seen at his flat in York Close, has no mobile phone or transport, and no next of kin or known close friends. He has been known to frequent the East Park, Southampton High Street, Above Bar and Bargate areas.
He is slim, unshaven and has grey receding hair. He could be wearing a black jacket and trousers or a long beige raincoat.
Police urge anyone who sees him to contact PC Suzanne Badham at Southampton Central on 101.