Firefighters are tackling a house on fire at Lawn Road in Portswood, close to Tennyson Road.
The house is reported to have been in a derelict condition and was due to be knocked down, and is now structurally unstable.
The front of the house is now reported to have fallen down completely.
Some reports indicate that the house was utilised by squatters for a period of time.
It is unclear whether anyone was in the house, or how the fire started.
Wessex Scene will keep you updated as this story develops.