A man has been stabbed on Gordon Avenue off Portswood Road.
The man, believed to be in his mid-20s, was standing on the pavement just after 18.00 when he was attacked.
Eyewitnesses at the scene, including staff at the Gordon Arms nearby, report seeing another man approach the victim on a bicycle before stabbing him and cycling away.
The man was lying in a pool of blood for over half an hour after the attack but remained conscious as paramedics treated him at the scene.
Several police cars and ambulances arrived as crowds began to gather at the entrance to Gordon Avenue, which has been cordoned off.
It is not known whether the men were acquainted prior to the attack.
The incident comes as the latest in a long line of violent assaults in the Portswood area.
Earlier this year, a man stumbled into the KFC on Portswood Road after being stabbed in the stomach by an unidentified assailant.
Last year a 21 year old female Southampton University student was also attacked in an incident on Gordon Avenue.
The Police are currently unavailable for comment, but are asking for anyone who was in the area at the time to come forward with any information by calling 101 or Crimestoppers anonymously on 0800 555111.